Not only will this damage them internally, but it can also make them extremely sensitive to sunlight. Most AIDS patients feel much better when taking hypericum, probably because of the antidepressant effect -- depression is probably the least often mentioned symptom of AIDS. No negative reactions on my part. Identifying St. John’s Wort Plants (Hypericum perforatum)The scientific name, Hypericum perforatum, actually gives a clue that’s really valuable for identifying the St. Johns Wort plant in the wild. Schey KL, et al. Schempp CM, et al. Vandenbogaerde AL, et al. Misinformed press reports warned that people taking St. John’s wort on a regular basis could put themselves at risk if they were exposed to bright light.13 These reports arose as a result of work carried out by Schey et al.14 This was an vitro study in which alpha-crystallins isolated from calf lenses were incubated in 50 micromolar hypericin (approximately 1,000 times therapeutic plasma concentrations) in the presence and absence of light. A characteristic metabolite of St. John's wort is the photodynamic active plant pigment hypericin. I suspected that incidents of phototox could be found somewhere, just couldn't come up with them. Regular internal use of St. John’s wort in whole-plant form (tea or tincture) does not appear to cause photosensitivity. Int J Biometeorol 1991;35:48-54. Examination was consistent with allodynia; St. John’s wort was withdrawn and symptoms began to improve in two weeks and disappeared over two months.   Animals will have blistering skin and white areas of the coat will easily sunburn. I set it free! Well, the way I hear it, old Dr. Kent had retired to practice in Montana and one day this basque sheepherder came into his office...) I have always tried my best to keep track of potential side-effects of herbs. Phototoxic effects of hypericum extract in cultures of human keratinocytes compared with those of psoralen. What is St. John’s Wort. From: Jonathan Treasure , >As to Hypericum perforatum (St. John's Wort) causing photosensitivity, Photoxicity of Hypericum in a small proportion of the (blonde) population has been clinically noted especially with topical application whether published or not. I am 33 and grew up on the beach and never had this before in my life. There are three sorts of photosensitisation. This has been demonstrated in a randomized, placebo-controlled trial in which fair-skinned subjects who burned easily were given metered doses of hypericum extract (LI 160) and were exposed to UVA and UVB irradiation.4 Hypericin and pseudohypericin plasma concentrations also were monitored. 14. View abstract. Kasper S, Schulz V. [High dose St. John’s wort extract as a phytogenic antidepressant]. Schempp et al also studied the effects of topical application of hypericum oil (hypericin 110 mcg/mL) and hypericum ointment (hypericin 30 mcg/mL) on skin sensitivity to solar simulated radiation.17 Sixteen volunteers received either oil (n = 8) or ointment (n = 8). St. John's Wort causes photosensitivity when ingested by livestock. St. John’s wort (Hypericum perforatum) is a plant with yellow flowers that grows in the wild, whose medicinal uses were first recorded in ancient Greece 2).The flowering tops of St. John’s wort are used to prepare teas, tablets, and capsules containing concentrated extracts. In order to avoid this, it is important that patients avoid direct sun exposure when possible. I know it has some drug interactions, luckily I am not taking any drugs so I did not find this to be a problem. Squueeezze that unopened flower bud...just a hint of yellow petals peaking so cautiously from its sepal safety...sqqqueeeezze and you will delight to find a drop of redness so strong as to dye the fingers. In 1999, alarm spread regarding the association of St. John’s wort with the development of cataracts. Disturbing, but true. Photosensitivity rarely is reported in St. John’s wort clinical trials; however, pale patients who burn easily may not realize they burn more easily. SSI sensitivity was the same in both groups after hypericum treatment. Irritability 12. It also helps cuts and external physical injuries in general. I would prefer to go a more natural route however, and have been researching St.John's wort as a natural alternative. Without exposure to sunlight....the herbs anti-viral effect dropped markedly. Med J Aust. This most common side effect that worries people of St John’s wort is photosensitivity. Hello! The one thing I am worried about is the photosensitivity. Dillon J. UV-B as a pro-aging and pro-cataract factor. Hello! Hautartz 1997;48:249-262. A study published in the European Journal of Clinical Pharmacology examined the side effect profile of St. John’s wort in detail (6). So I have begun taking 300 mg of St Johns Wort, 3 times a day -- along with some other supplements. St. John’s wort tea or tincture is a popular remedy for burns, sunburns, wounds, bruises, sores, insect bites, and cramps. There is really only one cause for St John’s wort poisoning and that cause is simply the ingestion of the plant by the horse. Would this be the cutting edge of herbal medicine through self experimentation (like those strange Northwestern Herbalists smoking Louseworts), or is ultrasound/herbal treatments a common practice amongst those folks at the conference? Anxiety 3. It's been online since 1995, and is run by Henriette Kress, a herbalist in Helsinki, Finland. Phototoxic photosensitivity from hypericum preparations appears to be due to the naphthodianthrones, hypericin, and pseudohypericin. Tierarztl Prax 1989;17:257-261. St. John's wort may pass into breast milk and may cause unwanted effects in a nursing baby. I just got 88 pages of bumpf from NAPRALERT on Hypericum and thereisn't a single mention of phototoxicity - so it seems that apart from a couple of anectdotal cases its not an issue as Michael Peggy Howie et aial say .... just keep away from the ultra sound gel in the solarium, Further to the Wort being a lover of roadsides etc Howie, it was widely distributed through Europe in Roman times by marching legionaries, who also used it soothe their sore feet. [Reversible increase in photosensitivity to UV-B caused by St. John's wort extract]. St John’s wort has been shown to have very low toxicity but a photosensitivity condition called hypericism has been recorded in animals. Restlessness 14. Low blood sugar levels (hypoglycemia) 13. 10. The most commonly reported adverse effects from St. John's wort include gastrointestinal symptoms, allergic reactions, dizziness, confusion, drowsiness, photosensitivity, and dry mouth. From mid-July to mid-August St. John's Wort blooms in dry sandy soil. He broke out in hives that lasted nearly a month. Is this something HE said? Therefore, the authors speculate that pseudohypericin, which is present in higher concentrations than hypericin in hypericum, may be of greater concern regarding phototoxicity.5 However, at steady state, plasma levels of pseudohypericin are only half that of hypericin.6. The inflammation is gone and I can bend the wrist backwards again. Schempp et al reported the high-performance liquid chromatographic detection of hypericin and pseudohypericin in human serum after oral administration of the hypericum extract LI 160 in 12 healthy volunteers.11 After single-dose administration of 1,800 mg hypericum, the mean serum level of total hypericins was 43 mcg/mL. The authors conclude that the results confirm a phototoxic effect of hypericin on human keratinocytes, but note that blood levels achieved with normal therapeutic use would be too low to induce phototoxic skin reactions. Photosensitivity causing dermatitis and inflammation of mucus membranes. This can lead to visual sensitivity to visible and ultraviolet light and to sunburns in situations that would not normally cause them. >I am much in support of bioregionalist solutions and actually got my B.S. John’s wort is also associated with photosensitivity and skin rash. The chemical alternatives have their dangers, too, including photosensitivity. In summer, many sheep suffered from inflammatory skin conditions around the ears, the eyes, and the bridge of the nose.1. Kumper H. [Hypericum poisoning in sheep]. Perhaps one shouldn't focus on the oddities and quirks of nature and coincidence....but I think it's cool. As most herbs, only using Hypericum for its anti-anxiety effects is to ignore the subtle shades and colors it causes as it moves INTO, THROUGH and OUT of the body. Available at: http://www.newscientist.com/ns/19990724/itnstory199907249.html. Sounds like a great contract for Dow Chemical, eh? Probably worth avoiding if you're already photosensitive; otherwise it seems to be rare and reasonably mild in its consequences. These hypericins are photoactive quinones that produce singlet oxygen and free radicals when exposed to light. Schempp CM, et al. I use it as my only sunscreen (and I am outside a lot) and find it not only immediately effective in preventing and treating sunburn, but even more protective with continuing use over years." No eye problems have been reported in any of the many trials involving St. John’s wort. Please click here to continue without javascript.. I have heard timberers insist that allowing further cutting in the Headwaters area is "bioregional" because the cutting of redwoods in the Pacific Northwest has historically been the base of a number of local economies. Photosensitivity may be possible from its ingestion. Is Hypersensitivity to Light a Side Effect of St. John’s Wort? Photodermatol Photoimmunol Photomed 2000;16:125-128. A few hours after sunbathing she developed symptoms on her arms and legs (again confined to sun-exposed skin). From: Michael Moore Hautarzt 1997;48:249-52. Intravenous administration of high-dose hypericin results in severe phototoxicity that precludes its clinical use. Anyone know a study that indicates photosensitivity in humans do to Hypericum? This is because direct sunshine during the hottest part of the day can actually burn it. Photosensitivity and St.Johns wort Jay__0__0. Peggy sez to Jonathan 1-800-370-9210 Schempp et al tested the immunomodulatory properties of topical preparations of hypericum and a synthesized constituent, hyperforin.16 They investigated the alloantigen function of human epidermal cells (EC) in vivo in a mixed EC lymphocyte reaction (MECLR). These levels are far below hypericin levels that are estimated to be phototoxic by these investigators (> 100 mcg/mL). I am taking St. John’s wort for depression. In a single-dose segment, 13 volunteers received placebo or a standardized hypericum extract (900, 1,800 or 3,600 mg, containing 0, 2.8, 5.6, and 11.3 mg of total hypericins [sum of hypericin and pseudohypericin]) in a double-blind, crossover design. Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John’s wort). Pharmacokinetics of hypericin and pseudohypericin after oral intake of the Hypericum perforatum extract LI 160 in healthy volunteers. If you have a condition or are taking medication that increases your skin's sensitivity to sunlight, talk with your doctor to weigh the risks. Photosensitivity and St.Johns wort Jay__0__0. Herbivorous animals that graze on St. John’s wort regularly can receive severe sunburns in addition to being poisoned by the plant. Some of the compounds found in this plant can trigger photosensitivity. He too was Black Irish. Did you know that St John's wort can cause extreme photosensitivity in many people? Internally using large amounts of hypericin, an isolated constituent of St. John’s wort, increases the likelihood of experiencing photosensitivity. Posted by Jay on June 02, 1999 at 08:40:48 My doctor prescribed Paxil for mild depression/anxiety. From this experience I learned that lesson that we seem to learn over and over again-that the land "lords" will take our very own words, concepts, and ideas and turn them into their own rhetoric. 3. And this even tempered plant grows in disturbed places...roadsides, lots, loves it when its been bulldozed a year or so ago. I figure the photosensitivity resulted from Maximum plasma concentration of hypericins was approximately 44 mcg/mL. First, St. John’s wort has the potential to cause photosensitivity (Hoffmann, 2003). There was no correlation between total hypericin plasma concentrations and photosensitivity. So I have begun taking 300 mg of St Johns Wort, 3 times a day -- along with some other supplements. 12. Hautarzt 1997;48:249-52. Drug interactions are reported among people who take Lamictal and St. john's wort. Without exposure to sunlight....the herbs anti-viral effect dropped markedly. Direct photosensitisation occurs when the chemical comes from a defect in the animals metabolism of its red blood cells, or, more commonly, from plants such as St. John’s wort. In both instances the herbs were taken internally and the media was a fresh tincture... appropriate, since the dry herb is nearly inert. Stomach discomfort 15. This may be an example of assumptive jumping from mammalian lab results to humans. 13. I have to say, this herb helps me a lot, I can feel it working. At baseline and then four hours after drug intake, subjects were exposed on small areas of their back to increasing doses of solar simulated irradiation (SSI, containing both UVA and UVB); another part was exposed to selective UVA irradiation. Sometimes folks break into mimicking the words, "social, historical, ecological, and economic," just as I now see people mimick, "body, mind, spirit," and "physical, mental, psychological, spiritual, and social." Another doctor showed us her legs at the conference -- she had used a hypericum ulstrasound gel to treat a sprained ankle. It’s understood that hypericin, the active ingredient in St John’s wort, is highly photoreactive by nature. It makes sense, then that phototoxicity was found at the higher, long-term usages (in addition to other factors). and H. formosum which we gathered during a couple of field trips. Two weeks ago, I spent the day at the beach and ended up with severe heat rash. By the way, who is this Berg guy. 8. Use has persisted in spite of later discovery that it doesn't help HIV in humans. Although the most common use of St. John’s wort in North America is for the treatment of depression, the traditional use of this herb includes its topical use for superficial wounds, burns (including sunburn), and dermatitis. From: moon2peg.NATURE.BERKELEY.EDU Common interactions include antinuclear antibody positive among females and affective disorder among males. >And so the authorities that be in charge (of cows and bugs, anyway) in Northern California has waged a war against the poor St. John, hapless victim of human transport from Europe. Many people use St. John's wort to help treat depression, anxiety, and ADHD. Ann Int Med 1999;130:510-514. A. This appears to work just fine, producing extracts of wond'rous redfulness. Topical St. John’s wort preparations appear to have low potential for photosensitization. Michael, don't despair. (540-610 nm). I have retailed and wholesaled herbs for 20 years and have taught and written about green stuff for 16 years (...and breathed and micturated for almost 54), and I have only run across 1 person to have shown signs of photosensitization from Hypericum. I don't have all that much experience with bipolar and other mental disorders and Hypericum...although I believe that consistant dosages long term is the way to go.......and careful with self medication. Answer: Photosensitization is unusual when it comes to St. John’s Wort. Date: Sat, 19 Nov 1994 22:22:54 -0800 New York: Springer Verlag; 1998:50-65. St. John’s Wort Tea Side Effects. According to the Sierra Club (March/April, 1994), the Pacific Coast "ecoregion" includes the pacific coast all the way down Baja and as far east as the Sierra Nevada, but does not include the Sierra Nevada! > Photoxicity of Hypericum in a small proportion of the (blonde) population has been clinically noted especially with topical application whether published or not. The authors suggest that this may provide a rationale for the traditional treatment of inflammatory skin disorders with hypericum extracts. While most photosensitizing meds react to UV (and sometimes also to blue light), St. John’s Wort — hypericum — photosensitizes to green light, right in the middle of the visual spectrum. Sundown Naturals Standardized St. John’s Wort contains a pretty standard 300 mg dosage of the raw plant materials from St. John’s wort, with 0.9 mg of standardized hypericum content. John’s wort is also associated with photosensitivity and skin rash. He had been bombed every day for a decade and I hadn't noticed. St John's wort does appear to have a more favourable short‐term safety profile than do standard antidepressants, a factor that is likely to be important in patients continuing to take medication. The international trade is wasteful, energy-expensive and miracle-pandering, and instead of dealing with herbs as perishable plant substances, the biological activity is often seriously impaired and many more plants are needed to produce a therapeutic activity. You should not use this product if you are trying to get pregnant. "), and was taking up to an ounce of the Hypericum tincture (1:2, fresh plant) a day...a truly excessive amount (it's an Irish thing, y'know?). Accessed December 1, 2000. (I even, being from the Mission district in San Francisco, include in my mailing address-Isley Creek, Shasta Bioregion, USA.) Wien Med Wochenschr 1999;149:191-196. Although St. John’s wort needs a fair bit of light to thrive, it does best in partial sun. (another anecdote not in NAPRALERT). This three-dimensional hologram of effects is what makes herbs superior to drugs... in a wholistic model...and makes drugs superior to herbs in a medical model. Cattle can eat some St. John’s Wort, but large amounts can cause photosensitivity and “hypericism,” a condition that could cause dehydration and death in the worst case, although weight loss (and thus lower market value) are more common. The medications omeprazole (Prilosec) and lansoprazole (Prevacid) may also increase the tendency of St. John's wort to cause photosensitivity. J Photochem Photobiol B 1998;45:87-94. I consider Hypericum to be safe...this is based on personally observing hundreds of people who haved used quality Hypericum preparations (...mine). St. John's wort should be removed entirley from the diet of the animal. I absolutely agree with you on the environmental impacts (and reduction in quality) that results from exotic and complicated herbal formulas. One of the well-known side effects is photosensitivity. July 24,1999. No change was apparent in visual erythema score after application of either hypericum oil or ointment. Fatigue 8. Minimal erythema dose was determined five, 20, and 68 hours after irradiation. If you crush the flowers between your fingers, it will leave a rusty reddish stain. The most common adverse effects are gastrointestinal symptoms, dizziness/confusion, and tiredness/sedation. I'm a healthy female that has been on St John's Wort for 2 weeks now. Taken in combination with other drugs, St John’s wort can boost the effect of the other drug, which then increases the risk of negative reactions. St. John’s wort (both oral or topical) can also increase the sensitivity of your skin and eyes to sunlight. It is doubtful that medicine will be able to do much more than bandaid repairs as the environment holds more and more complex organics capable of finding THE constitutional weak link in our metabolism. Lancet 1998;352: St John’s wort may also impact on the breakdown of other drugs by The results suggested a trend toward increased photosensitivity that might become relevant in fair-skinned individuals, in diseased skin, or after extended sun exposure. Severe cutaneous phototoxicity (an erythematous rash associated with painful dysesthesias involving the areas exposed to light) was observed in 11 of 23 subjects. General Care and Feeding. Hypericin induced photo-polymerization of crystallins in the presence of light. The photosensitizing effects of topical hypericum also have been studied and appear to be much more mild than the effects of oral or intravenous administration. 11. AIDS patients started taking hypericum when is was found that the hypericin had an anti-HIV effect in mice. The clinical implications of this are unclear. I do know that some common psychiatric pharmaceuticals DO cause photosensitivity in humans....... And when you hold the leaves of the hypericum perforatum the the light of the sky you will see little holes...actually compartments (perforations)....that trap and use the energy of the sun to run a biochemical factory......making hypericin....the red colored constituent assumed to be one of the active ones. A calming herb that grows all over disturbed areas...hmmmmm. By the way, she said the only thing that would help the severe pain was aloe vera gel. Local herbalism means more "medicine" from fewer plants. Skin Pharmacol Appl Skin Physiol 1999;12:299-304. Identifying St. John’s Wort Plants (Hypericum perforatum)The scientific name, Hypericum perforatum, actually gives a clue that’s really valuable for identifying the St. Johns Wort plant in the wild. It’s now May. I have not heard of one case of human photosensitivity...even in the blond, blue-eyed, fair skinned ones...from standard dosages of tinture. It is known that hypericin may cause a severe photodermatitis called hypericism when higher amounts of St. John's wort are ingested orally. Henriette's herbal is one of the oldest and largest herbal medicine sites on the net. With many of these kinds of problems.....you may not be able to tell if it's working...especially since you started taking it and you feel great...I mean really good...as you swing up into a manic phase and over one edge or the other. First noted in animals that grazed in fields dotted with St. John’s wort, an early report was about a case of St. John’s wort poisoning in German Blackface sheep. Still, I believe that the average user treating depression shouldn't shy away from trying this Wort. Dr. Cott is Scientific Director and Chief Science Officer at Scientific Herbal Products, Inc. in College Park, MD. That is, until the Sierra Club got a hold of it and created totally new bioregions nationwide without any concern for the social, historical, and economic aspects. I only warn that, in my experience, I have heard the word denuded of its original meaning to the point that it is used as justification for slicing down our redwood kin. But of interest to me was the notion that sunlight increased the Wort's anti-viral effects........that sun again......somehow..in some mysterious way linked to this plant and it's effects. He was a student of mine in an 8-month program a few years ago. I actually took a botany class at UC Berkeley (CA Native Plantlife) in which one of the wonderous professors suggested covering large areas of the Central Valley with black plastic in order to eradicate St. John's Wort. Staffeldt B, et al. Despite the benefits, some of the potential side effects of this herbal tea include photosensitivity, complications with surgery, and issues for pregnant and breastfeeding women.. Photosensitivity: Some people have reported increased photosensitivity when consuming this tea; if you feel like your eyes are extra sensitive to sunlight, stop drinking this tea. Because hypericin has demonstrated significant antiviral activity in vitro, a Phase I safety study using intravenous synthetic hypericin was performed in 30 HIV-infected adults.7 All patients receiving multiple intravenous. There was scarring from the blisters. View abstract. I don't think many would, but there you go. In the multiple dose segment, 50 volunteers received 600 mg hypericum extract tid (twice the normal recommended dose) with a daily dose of 5.6 mg of total hypericin. Effect of topical application of Hypericum perforatum extract (St. John’s wort) on skin sensitivity to solar simulated radiation. 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