Schempp et al tested the immunomodulatory properties of topical preparations of hypericum and a synthesized constituent, hyperforin.16 They investigated the alloantigen function of human epidermal cells (EC) in vivo in a mixed EC lymphocyte reaction (MECLR). These levels are far below hypericin levels that are estimated to be phototoxic by these investigators (> 100 mcg/mL). I am taking St. John’s wort for depression. In a single-dose segment, 13 volunteers received placebo or a standardized hypericum extract (900, 1,800 or 3,600 mg, containing 0, 2.8, 5.6, and 11.3 mg of total hypericins [sum of hypericin and pseudohypericin]) in a double-blind, crossover design. Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John’s wort). Pharmacokinetics of hypericin and pseudohypericin after oral intake of the Hypericum perforatum extract LI 160 in healthy volunteers. If you have a condition or are taking medication that increases your skin's sensitivity to sunlight, talk with your doctor to weigh the risks. Photosensitivity and St.Johns wort Jay__0__0. Herbivorous animals that graze on St. John’s wort regularly can receive severe sunburns in addition to being poisoned by the plant. Some of the compounds found in this plant can trigger photosensitivity. He too was Black Irish. Did you know that St John's wort can cause extreme photosensitivity in many people? Internally using large amounts of hypericin, an isolated constituent of St. John’s wort, increases the likelihood of experiencing photosensitivity. Posted by Jay on June 02, 1999 at 08:40:48 My doctor prescribed Paxil for mild depression/anxiety. From this experience I learned that lesson that we seem to learn over and over again-that the land "lords" will take our very own words, concepts, and ideas and turn them into their own rhetoric. 3. And this even tempered plant grows in disturbed places...roadsides, lots, loves it when its been bulldozed a year or so ago. I figure the photosensitivity resulted from Maximum plasma concentration of hypericins was approximately 44 mcg/mL. First, St. John’s wort has the potential to cause photosensitivity (Hoffmann, 2003). There was no correlation between total hypericin plasma concentrations and photosensitivity. So I have begun taking 300 mg of St Johns Wort, 3 times a day -- along with some other supplements. 12. Hautarzt 1997;48:249-52. Drug interactions are reported among people who take Lamictal and St. john's wort. Without exposure to sunlight....the herbs anti-viral effect dropped markedly. Direct photosensitisation occurs when the chemical comes from a defect in the animals metabolism of its red blood cells, or, more commonly, from plants such as St. John’s wort. In both instances the herbs were taken internally and the media was a fresh tincture... appropriate, since the dry herb is nearly inert. Stomach discomfort 15. This may be an example of assumptive jumping from mammalian lab results to humans. 13. I have to say, this herb helps me a lot, I can feel it working. At baseline and then four hours after drug intake, subjects were exposed on small areas of their back to increasing doses of solar simulated irradiation (SSI, containing both UVA and UVB); another part was exposed to selective UVA irradiation. Sometimes folks break into mimicking the words, "social, historical, ecological, and economic," just as I now see people mimick, "body, mind, spirit," and "physical, mental, psychological, spiritual, and social." Another doctor showed us her legs at the conference -- she had used a hypericum ulstrasound gel to treat a sprained ankle. It’s understood that hypericin, the active ingredient in St John’s wort, is highly photoreactive by nature. It makes sense, then that phototoxicity was found at the higher, long-term usages (in addition to other factors). and H. formosum which we gathered during a couple of field trips. Two weeks ago, I spent the day at the beach and ended up with severe heat rash. By the way, who is this Berg guy. 8. Use has persisted in spite of later discovery that it doesn't help HIV in humans. Although the most common use of St. John’s wort in North America is for the treatment of depression, the traditional use of this herb includes its topical use for superficial wounds, burns (including sunburn), and dermatitis. From: moon2peg.NATURE.BERKELEY.EDU Common interactions include antinuclear antibody positive among females and affective disorder among males. >And so the authorities that be in charge (of cows and bugs, anyway) in Northern California has waged a war against the poor St. John, hapless victim of human transport from Europe. Many people use St. John's wort to help treat depression, anxiety, and ADHD. Ann Int Med 1999;130:510-514. A. This appears to work just fine, producing extracts of wond'rous redfulness. Topical St. John’s wort preparations appear to have low potential for photosensitization. Michael, don't despair. (540-610 nm). I have retailed and wholesaled herbs for 20 years and have taught and written about green stuff for 16 years (...and breathed and micturated for almost 54), and I have only run across 1 person to have shown signs of photosensitization from Hypericum. I don't have all that much experience with bipolar and other mental disorders and Hypericum...although I believe that consistant dosages long term is the way to go.......and careful with self medication. Answer: Photosensitization is unusual when it comes to St. John’s Wort. Date: Sat, 19 Nov 1994 22:22:54 -0800 New York: Springer Verlag; 1998:50-65. St. John’s Wort Tea Side Effects. According to the Sierra Club (March/April, 1994), the Pacific Coast "ecoregion" includes the pacific coast all the way down Baja and as far east as the Sierra Nevada, but does not include the Sierra Nevada! > Photoxicity of Hypericum in a small proportion of the (blonde) population has been clinically noted especially with topical application whether published or not. The authors suggest that this may provide a rationale for the traditional treatment of inflammatory skin disorders with hypericum extracts. While most photosensitizing meds react to UV (and sometimes also to blue light), St. John’s Wort — hypericum — photosensitizes to green light, right in the middle of the visual spectrum. Sundown Naturals Standardized St. John’s Wort contains a pretty standard 300 mg dosage of the raw plant materials from St. John’s wort, with 0.9 mg of standardized hypericum content. John’s wort is also associated with photosensitivity and skin rash. He had been bombed every day for a decade and I hadn't noticed. St John's wort does appear to have a more favourable short‐term safety profile than do standard antidepressants, a factor that is likely to be important in patients continuing to take medication. The international trade is wasteful, energy-expensive and miracle-pandering, and instead of dealing with herbs as perishable plant substances, the biological activity is often seriously impaired and many more plants are needed to produce a therapeutic activity. You should not use this product if you are trying to get pregnant. "), and was taking up to an ounce of the Hypericum tincture (1:2, fresh plant) a day...a truly excessive amount (it's an Irish thing, y'know?). Accessed December 1, 2000. (I even, being from the Mission district in San Francisco, include in my mailing address-Isley Creek, Shasta Bioregion, USA.) Wien Med Wochenschr 1999;149:191-196. Although St. John’s wort needs a fair bit of light to thrive, it does best in partial sun. (another anecdote not in NAPRALERT). This three-dimensional hologram of effects is what makes herbs superior to drugs... in a wholistic model...and makes drugs superior to herbs in a medical model. Cattle can eat some St. John’s Wort, but large amounts can cause photosensitivity and “hypericism,” a condition that could cause dehydration and death in the worst case, although weight loss (and thus lower market value) are more common. The medications omeprazole (Prilosec) and lansoprazole (Prevacid) may also increase the tendency of St. John's wort to cause photosensitivity. J Photochem Photobiol B 1998;45:87-94. I consider Hypericum to be safe...this is based on personally observing hundreds of people who haved used quality Hypericum preparations (...mine). St. John's wort should be removed entirley from the diet of the animal. I absolutely agree with you on the environmental impacts (and reduction in quality) that results from exotic and complicated herbal formulas. One of the well-known side effects is photosensitivity. July 24,1999. No change was apparent in visual erythema score after application of either hypericum oil or ointment. Fatigue 8. Minimal erythema dose was determined five, 20, and 68 hours after irradiation. If you crush the flowers between your fingers, it will leave a rusty reddish stain. The most common adverse effects are gastrointestinal symptoms, dizziness/confusion, and tiredness/sedation. I'm a healthy female that has been on St John's Wort for 2 weeks now. Taken in combination with other drugs, St John’s wort can boost the effect of the other drug, which then increases the risk of negative reactions. St. John’s wort (both oral or topical) can also increase the sensitivity of your skin and eyes to sunlight. It is doubtful that medicine will be able to do much more than bandaid repairs as the environment holds more and more complex organics capable of finding THE constitutional weak link in our metabolism. Lancet 1998;352: St John’s wort may also impact on the breakdown of other drugs by The results suggested a trend toward increased photosensitivity that might become relevant in fair-skinned individuals, in diseased skin, or after extended sun exposure. Severe cutaneous phototoxicity (an erythematous rash associated with painful dysesthesias involving the areas exposed to light) was observed in 11 of 23 subjects. General Care and Feeding. Hypericin induced photo-polymerization of crystallins in the presence of light. The photosensitizing effects of topical hypericum also have been studied and appear to be much more mild than the effects of oral or intravenous administration. 11. AIDS patients started taking hypericum when is was found that the hypericin had an anti-HIV effect in mice. The clinical implications of this are unclear. I do know that some common psychiatric pharmaceuticals DO cause photosensitivity in humans....... And when you hold the leaves of the hypericum perforatum the the light of the sky you will see little holes...actually compartments (perforations)....that trap and use the energy of the sun to run a biochemical factory......making hypericin....the red colored constituent assumed to be one of the active ones. A calming herb that grows all over disturbed areas...hmmmmm. By the way, she said the only thing that would help the severe pain was aloe vera gel. Local herbalism means more "medicine" from fewer plants. Skin Pharmacol Appl Skin Physiol 1999;12:299-304. Identifying St. John’s Wort Plants (Hypericum perforatum)The scientific name, Hypericum perforatum, actually gives a clue that’s really valuable for identifying the St. Johns Wort plant in the wild. It’s now May. I have not heard of one case of human photosensitivity...even in the blond, blue-eyed, fair skinned ones...from standard dosages of tinture. It is known that hypericin may cause a severe photodermatitis called hypericism when higher amounts of St. John's wort are ingested orally. Henriette's herbal is one of the oldest and largest herbal medicine sites on the net. With many of these kinds of problems.....you may not be able to tell if it's working...especially since you started taking it and you feel great...I mean really good...as you swing up into a manic phase and over one edge or the other. First noted in animals that grazed in fields dotted with St. John’s wort, an early report was about a case of St. John’s wort poisoning in German Blackface sheep. Still, I believe that the average user treating depression shouldn't shy away from trying this Wort. Dr. Cott is Scientific Director and Chief Science Officer at Scientific Herbal Products, Inc. in College Park, MD. That is, until the Sierra Club got a hold of it and created totally new bioregions nationwide without any concern for the social, historical, and economic aspects. I only warn that, in my experience, I have heard the word denuded of its original meaning to the point that it is used as justification for slicing down our redwood kin. But of interest to me was the notion that sunlight increased the Wort's anti-viral effects........that sun again......somehow..in some mysterious way linked to this plant and it's effects. He was a student of mine in an 8-month program a few years ago. I actually took a botany class at UC Berkeley (CA Native Plantlife) in which one of the wonderous professors suggested covering large areas of the Central Valley with black plastic in order to eradicate St. John's Wort. Staffeldt B, et al. Despite the benefits, some of the potential side effects of this herbal tea include photosensitivity, complications with surgery, and issues for pregnant and breastfeeding women.. Photosensitivity: Some people have reported increased photosensitivity when consuming this tea; if you feel like your eyes are extra sensitive to sunlight, stop drinking this tea. Because hypericin has demonstrated significant antiviral activity in vitro, a Phase I safety study using intravenous synthetic hypericin was performed in 30 HIV-infected adults.7 All patients receiving multiple intravenous. There was scarring from the blisters. View abstract. I don't think many would, but there you go. In the multiple dose segment, 50 volunteers received 600 mg hypericum extract tid (twice the normal recommended dose) with a daily dose of 5.6 mg of total hypericin. Effect of topical application of Hypericum perforatum extract (St. John’s wort) on skin sensitivity to solar simulated radiation. 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